摘要
A chiral stationary phase for naproxen separation was prepared by means of molecular imprinting, in which acrylamide and ethylene glycol dimethacrylate were copolymerized in the presence of template. Racemic naproxen was efficiently resolved on the molecular imprinting polymer. The concentration of acetic acid in the mobile phase was optimized. A new affinity chromatography model using molecular imprinting was established by which the agreement between the simulated and experimental results was obtained. The results suggested that affinity chromatography mechanism controled the retention in this system.
A chiral stationary phase for naproxen separation was prepared by means of molecular imprinting, in which acrylamide and ethylene glycol dimethacrylate were copolymerized in the presence of template. Racemic naproxen was efficiently resolved on the molecular imprinting polymer. The concentration of acetic acid in the mobile phase was optimized. A new affinity chromatography model using molecular imprinting was established by which the agreement between the simulated and experimental results was obtained. The results suggested that affinity chromatography mechanism controled the retention in this system.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2002年第11期2073-2075,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金 (批准号 :2 9976 0 0 4)
教育部优秀青年教师奖励基金资助
