系统性红斑狼疮治疗与病情活动性研究

Study of Systemic Lupus Erythematosus (SLE) Treatment and Disease Activity

目的 探讨治疗过程中系统性红斑狼疮 (SLE)患者病情活动的变化及临床意义。方法 回顾 2 86例SLE患者病历资料 ,动态比较不同病程的系统性红斑狼疮疾病活动指数 (SLEDAI)变化情况。结果 首诊时病程为 <1月组患者和 1～ 3月组患者的SLEDAI值低于 4～ 6月及 >6月组患者 ;治疗后SLEDAI值显著低于初始值 ,且治疗后 2月～ 3年间SLEDAI值高于其它各时期。SLEDAI值同皮质类固醇激素治疗总量不相关。结论 至首诊时病程短的患者 ,治疗可在一定程度上迅速有效缓解SLE病情活动 ;而至首诊时病程长的患者病情缓解相对较慢。SLE治疗后 2月～ 3年病情较活跃 ,易出现内脏损害 ,值得重视。

Objective To investigate the changes of disease activity and clinical significance in the course of treatment in patients with SLE.Method 286 cases of SLE were reviewed and compared the changes of SLEDAI scores in different disease duration.Results The SLEDAI scores of patients whose first treatment courses less than 1 month and 1 to 3 months were significantly lower than those patients whose were 4 to 6 months and more than 6 months. After treatment for 2 months to 3 years, the SLEDAI scores were not correlated with cumulated dosage of corticosteroids.Conclusions For the patients of short first treatment course, the treatment could relieve SLE disease activity rapidly and effectively to some extent; while for the patients whose first treatment courses were relatively long ,the relif of disease activity was relatively slow. After treatment for 2 to 3 months, the disease of SLE patients was more active than other periods, and it was inclined to produce visceral damage. As mentioned above ,we should pay attention to this phenomenon.