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2型糖尿病合并胆石症与血胰岛素和脂类代谢的关系 被引量:3

Relationship Between Plasma Insulin,Serum Lipids and Cholelithiasis in Patients With Type 2 Diabetes
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摘要 目的 了解非胰岛素依赖型糖尿病 (NIDDM)合并胆石症患者血中胰岛素水平和脂质代谢方面的改变。方法 分别采集 15 9例我院近 3年来内分泌科门诊及住院NIDDM病人空腹和餐后 2h血样 ,检测血清中血糖、血脂、载脂蛋白A1和B、胰岛素含量 ,观察比较 2型糖尿病合并胆石症 (10 3例 )与不合并胆石症患者 (5 6例 )血清中相关指标的差异。结果 NIDDM合并胆石症患者以女性居多 ,既往高峰体质指数和血液中甘油三酯、胰岛素水平和胰岛素敏感指数、载脂蛋白A1和B、明显高于无胆石组 ;而年龄、病程、血糖、高密度脂蛋白与低密度脂蛋白等无显著性差异。结论 NIDDM合并胆石症可能与肥胖、高胰岛素血症和胰岛素抵抗以及脂类代谢紊乱有关。 Objective To investigate the level changes of plasma insulin,serum lipids in type 2 diabetes with cholelithiasis.Methods 159 cases of types 2 diabetic patients was studied during recently 3 years in our department of endocrinology,the levels of blood glucose,plasma insulin and insulin sensitivity index(ISI),serum lipids,apolipoproteins(ApoA 1,B) were measured both fasting and post-prandial,and investigated their correlation between type 2 diabetic patients with cholelithiasis(n=103) and without cholelithiasis(n=56).Results Female was predominated in fifty-six diabetic with cholelithiasis,they had higher triglyceride(TG),fasting or post-prandial insulins,ApoA 1,ApoB,the top body weight index and lower ISI than 103 diabetics without cholelithiasis.There were no significant differences in total cholesterol(CH),HDL-Ch,LDL-Ch,blood glucose concentrations between the groups.Conclusions Obesity,insulin resistance and lipids metabolic disturbance might be related to the development of cholelithiasis in type 2 diabetic patients.
出处 《中国医师杂志》 CAS 2002年第11期1220-1221,共2页 Journal of Chinese Physician
关键词 2型糖尿病 胆石症 脂类代谢 合并症 胰岛素 胰岛素抵抗 NIDDM Cholelithiasis Diabetes Insulin Insulin resistance Lipids
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