人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种作用的计算机模拟研究(英文)

Computer Simulation for Effect of Pr(Ⅲ) on Zn(Ⅱ) Speciation in Human Interstitial Fluid

建立了人体细胞间液多相模型,研究了人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种的作用。结果表明,Pr(Ⅲ)能够影响Zn(Ⅱ)的物种分布。Zn(Ⅱ)主要分布于[Zn(HSA)],[Zn(IgG)]和 [Zn(Cys)2 H]中。Pr(Ⅲ)不能与Zn(Ⅱ)竞争HSA和IgG配体;但是,Pr(Ⅲ)能够与Zn(Ⅱ)竞争磷酸盐和碳酸盐配体,这会引起Zn(Ⅱ)

A muti phase model of metal ion speciation in human interstitial fluid has been constructed and the effect of Pr(Ⅲ) on Zn(Ⅱ) speciation has also been studied. Results show that Pr(Ⅲ) ions influence the distribution of Zn(Ⅱ) species. Zn(Ⅱ) is mainly distributed as \, \ and \[Zn(Cys) 2 H\]. Pr(Ⅲ) can not compete with Zn(Ⅱ) to form HSA and IgG complex, while it can compete with Zn(Ⅱ) as phosphate and carbonate, causing the redistribution of Zn(Ⅱ) species.