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肿瘤抑制因子PTEN蛋白在成年大鼠腰段脊髓和背根节中的表达与分布 被引量：2

EXPRESSION AND DISTRIBUTION OF PTEN PROTEIN IN LUMBAR SPINAL CORD AND DRG OF ADULT RAT
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摘要 目的　观察肿瘤抑制因子PTEN蛋白在成年大鼠腰段脊髓和背根节中的表达和分布。　方法　免疫组织化学ABC法显示大鼠脊髓和背根神经节中PTEN阳性免疫反应产物。　结果　背根节神经元及穿越背根节神经纤维轴突有阳性免疫反应产物存在 ;PTEN阳性免疫反应产物在脊髓主要位于灰质神经元。　结论　PTEN在成年大鼠腰段脊髓和背根节神经元及神经纤维轴突中表达。 Objective To investigate the expression and distribution of PTEN protein in lumbar spinal cord and DRG of adult rat. Methods Immunohistochemical stain was used to demonstrate the PTEN\|like positive immunohistochemical product. Results The positive PTEN immunoreactivity presented in the neurons of lumbar spinal cord and DRG as well as the axon of nerve fibers passing through the DRG.Conclusion\ The present results suggested that PTEN protein expresses in the neurons of lumbar spinal cord and DRG as well as the axon of nerve fiber.\;[
作者 严志强 张沛云 王晓冬 徐邦生 衣昕
机构地区 南通医学院江苏省神经再生重点实验室
出处 《解剖学报》 CAS CSCD 北大核心 2002年第6期587-589,共3页 Acta Anatomica Sinica
关键词 肿瘤抑制因子 PTEN 腰段脊髓 蛋白表达 成年大鼠 免疫组织化学ABC法 背根节 PTEN Spinal cord Dorsal root ganglia Rat
分类号 R338.2 [医药卫生—人体生理学]
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参考文献7

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同被引文献18

  • 1Yamada K M,Araki M.Tumor suppressor PTEN:modulator of cell signaling,growth,migration and apoptosis[J].J Cell Sci,2001,114(Pt 13):2375-2382.
  • 2Lachyankar M B,Sultana N,Schonhoff C M,et al.A role for nuclear PTEN in neuronal differentiation[J].J Neurosci,2000,20(4):1404-1413.
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  • 7Weng L P,Brown J L,Baker K M,et al.PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase,independently of the phosphoinositide 3-kinase pathway[J].Hum Mol Genet,2002,11(15):1687-1696.
  • 8Marino S,Krimpenfort P,Leung C,et al.PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum[J].Development,2002,129(14):3513-3522.
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  • 10Yamada KM,Araki M.Tumor suppressor PTEN:modulator of cell signaling,growth,migration and apoptosis.J Cell Sci,2001,114:2375～2382.

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解剖学报
2002年 第6期

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