胃力康颗粒与H_2受体拮抗剂联合抗生素治疗消化性溃疡临床观察

Weilikang and H_2-receptor blocker in combination with antibiotic in the treatment of active peptic ulcer

目的:研究胃力康颗粒用于治疗消化性溃疡的疗效及安全性。方法:将经胃镜证实的消化性溃疡患者随机分成治疗组36例和对照组38例,治疗组应用胃力康颗粒10g,1日3次口服,连服4周;西米替丁0.2g,1日3次口服,0.4g每晚睡前口服,连服4周;阿莫西林0.5g,1日3次口服,连服2周。对照组应用硫糖铝1.0g,1日3次口服,连服4周,西米替丁及阿莫西林同治疗组。治疗前后分别做胃镜检查,治疗期间每周随访一次,并记录症状改善情况及不良反应。结果:治疗组溃疡愈合率和总有效率分别为94.4%和97.2%,而对照组分别为94.8%和97.4%,两组比较差异无显著性(P>0.05)各项症状改善情况两组相仿(P>0.05)。治疗期间两组均有良好的耐受性。结论:胃力康颗粒对消化溃疡疗效确切,是一种良好的抗溃疡药物。

Objective: To study the efficacy and safety of weilikang in treatment of active peptic ulcer. Methods: 74 patients with active peptic ulcer were at random divided into two groups: experimental group(36) and control group(38). Experimental group received weilikang Cimetidinum and Armocilin, and control group recieved liutanglu and others. Both took for 4 weaks. Results: After 4 weeks?treatment, healing rate. and effective rate of experimental group were 94.4% and 97.2%, and those of control group were 94.8% and 97.4%(P>0.05). Conclusions: In the study, weilikang producea healing rate equivalent to control group in active peptic ulcer and achieved the same symptoms relieving rate.Weilikang was well tolerated.