草珊瑚口腔膏治疗复发性口腔溃疡52例

Caoshanhu Oral Plaster in the Treatment of 52 Patients with Recurrent Oral Ulcers

目的 :评价草珊瑚口腔膏治疗复发性口腔溃疡的疗效。方法 :复发性口腔溃疡 10 2例随机分为两组 ,治疗组 5 2例采用草珊瑚口腔膏局部外涂 ,对照组 5 0例采用甲硝唑糊剂局部外涂 ,两组均每日 3或 4次。观察两组不同时间内疗效 ,并追踪 1a内口腔溃疡复发情况。结果 :治疗组显效、有效、无效分别为 2 7,2 5 ,0例 ,有效率 10 0 .0 % ;对照组显效、有效、无效分别为 15 ,2 4,11例 ,有效率 78.0 %。治疗组明显优于对照组 (P <0 .0 5 )。治疗组 1a复发率明显低于对照组 (P <0 .0 1)。除对照组 2例感觉局部刺痛外无不良反应。结论 :草珊瑚口腔膏治疗复发性口腔溃疡有较好的临床疗效。

Objective:To appraise the effect of caoshanhu (CSH) oral plaster in the treatment of recurrent oral ulcers (ROU). Methods:102 patients with ROU were randomly divided into 2 groups. 52 patients of the treatment group were treated by local painting with CSH oral plaster t.i.d or b.i.d. while 50 patients of the control group, with metronidazole plaster, t.i.d or b.i.d., as well. Thera peutic effectiveness in patients of both groups was kept under observation in different time periods during the treatment and an one year follow up survey carried out for the occurence of relapse of oral ulcers. Results:The numbers of cases found to be 'strikingly effective', 'effective' and 'ineffective' in the treatment group were 27,25 and 0, respectively. The overall effective rate was 100.0%. In contrast, those parameters in the control group were 15, 24 and 11, respectively, the overall effective rate being 78.0%. The effect was significantly better in the treatment group ( P <0.05). No adverse reactions were noted except that two patients of the control group complained of local stabbing pain. Conclusion:CSH oral plaster was shown to have good clinical therapeutic effect in the treatment of ROU.