p27蛋白和细胞周期素D_1在喉鳞状细胞癌中的表达及意义

Expression of p27 protein and cyclinD_1 in laryngeal carcinoma

目的 :探讨喉癌及癌旁组织中抑癌基因p2 7及癌基因细胞周期素D1的表达状况 ,以及p2 7与细胞周期素D1的表达与喉癌临床特征之间的关系。方法 :用免疫组织化学S P法对 38例喉癌组织 ,癌旁组织进行p2 7及细胞周期素D1检测。结果 :p2 7及细胞周期素D1表达在喉癌和癌旁组织之间各有统计学差异。p2 7及细胞周期素D1表达与颈淋巴结转移和患者预后有相关性 (P <0 .0 5 ) ;且大多数受检喉癌组织中 ,p2 7与细胞周期素D1呈反方向表达。结论 :检测p2 7与细胞周期素D1有助于判断喉癌预后。

Objective:To find out whether the expression of p27 and cyclin D 1 is different in laryngeal squamous cell carcinoma and the edge tissues, and to study the relationship between the expression of p27 and cyclin D 1 with the clinic character in patients with laryngeal squamous cell carcinoma.Method:An immunohistochemistry method was used to study the expression of p27 protein and cyclinD 1 in 38 laryngeal squamous cell carcinoma and the edge tissues.Result:The expression of p27 protein and cyclinD 1 was significantly different between the laryngeal carcinoma and the edge tissue. Low expression of p27 and over expression of cyclinD 1 was associated with the liability of lymph node metastasis and the poor prognosis for patient with laryngeal squamous cell carcinoma. An interesting observation was that the inverse expression between p27 and cyclinD 1 might play an important role in laryngeal squamous cell carcinoma.Conclusion:p27 protein and cyclinD 1 in laryngeal carcinoma is apparently a significance predictor of survival.