摘要
目的 :探讨IL 8在喉癌及癌边缘组织中的表达及其与喉癌生物学行为的关系。方法 :采用免疫组化SABC方法对 35例原发喉癌及癌边缘 1.0cm组织中的IL 8进行检测。结果 :喉癌组中 2 4例阳性 (6 8.6 % ) ,癌旁组中 15例阳性 (42 .9% ) ,喉癌组与癌旁组阳性率之间差异显著 (P <0 .0 5 ) ;肿瘤发生部位、分化程度及是否有淋巴结转移差异不显著。结论 :提示IL 8在喉癌中可能起着一定的作用 ;其在喉癌中的高表达可能与患者的病程及免疫状态有关。
Objective:To explore the expression of IL 8 on laryngeal carcinoma and the edge tissues and its relationship with the character of laryngeal carcinoma.Method:Immunohistochemical SABC detections were carried out in 35 case of original laryngeal cancer and the edge tissues( 1.0 cm near the tumor).Result:the positive rate was 68.6 % in 24 case of carcinoma group, 42.9 % in 15 case of edge group. The statistical difference between carcinoma group with edge group was very significant(P< 0.05 ). The expression of IL 8 had no difference in location, tumor developed degree and lymph metastases.Conclusion:The expression of IL 8 may play an important role in the process of laryngeal cancer and the patients' immune stage.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2002年第12期672-673,共2页
Journal of Clinical Otorhinolaryngology
关键词
IL-8
喉癌
癌边缘组织
表达
Laryngeal neoplasms
Interleukin 8
Immunohistochemistry
