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肺癌早期基因诊断研究进展 被引量:5

Recent advances of early genetic diagnosis for lung cancer
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摘要 肺癌早期或癌前病变时即已发生多种基因异常 ,这些异常改变往往先于临床症状的出现 ,并在一定程度上成为早期肺癌的分子标志物。应用基因检测技术对肺癌高危人群 ,特别是有家族倾向或重度吸烟伴气道阻塞者的痰或血液进行相关基因的检测有助于肺癌的早期诊断 ,是提高肺癌患者生存率的关键所在。
作者 齐协飞
出处 《国外医学(肿瘤学分册)》 2002年第6期426-429,共4页 Foreign Medical Sciences (Cancer Section)
基金 江西省卫生厅重大招标项目
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参考文献10

  • 1Ahrendt SA,Chow JT,Xu LH,et al.Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer[].Journal of the National Cancer Institute.1999
  • 2Niklinski J,Niklinska W,Chyczewski L,et al.Molecular genetic abnormalities in premalignant lung lesions: biological and clinical implications[].European Journal of Cancer Prevention.2001
  • 3Zhou J,Nong L,Wloch M,et al.Expression of early lung cancer detection marker: hnRNP-A2 B1 and its relation to microsatellite alteration in non-small cell lung cancer[].Lung Cancer.2001
  • 4Wimmel A,Kogan E,Ramaswamy A,et al.Variant expression of CD44 in preneoplastic lesions of the lung[].Cancer.2001
  • 5De Flora S,Izzotti A,D′Agostini F,et al.Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points[].Carcinogenesis.2001
  • 6Hirsch FR,Franklin WA,Gazdar AF,et al.Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology[].Clinical Cancer Research.2001
  • 7Minamoto T,Mai M,Ronai Z.K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers[].Cancer Detection and Prevention.2000
  • 8Castaldo G,Tomaiuolo R,Sanduzzi A,et al.Lung cancer metastatic cells detected in blood by reverse transcriptase polymerase chain reaction and dot-blot analysis[].Journal of Clinical Oncology.1997
  • 9Kurusu Y,Yamashita J,Ogawa M.Detection of circulating tumor cells by reverse transcriptase-polymerase chain reaction in patients with resectable non-small-cell lung cancer[].Journal of Surgery.1999
  • 10Mao L,Hruban RH,Boyle JO,et al.Detection of oncogene mutations in sputum precedes diagnosis of lung cancer[].Cancer Research.1994

同被引文献39

  • 1杨传标,薛军,叶玉坤,徐克成.肺癌相关基因检测用于肺癌早期诊断研究进展[J].肿瘤学杂志,2004,10(5):360-362. 被引量:2
  • 2黄淑红,马晓丽,邱超,黄敬爱,孔维华,谢经武,张红卫.Cyclin B1、CDK1在肺癌中过表达及其意义[J].山东大学学报(理学版),2004,39(5):122-124. 被引量:4
  • 3杨艳,曹箭.肺癌早期诊断相关标记物的研究进展[J].诊断病理学杂志,2007,14(3):229-231. 被引量:3
  • 4Yu J,Dubeau L. Telomerase and maliagnant transformation[J].Cancer TreatRes,2002,107(1):213-228.
  • 5Saldanha S N, Andrews L G, Tollefsbol T O. Analysis of telomerase activity anddetection of its catalytic subunit, hTERT [J]. Anal Biochem,2003,315(1) :1-21.
  • 6Komiya T, Kawase I, Nitta T, et al. Prognostic significance of hTERT expression innon-small cell lung cancer[J]. Int J Oncol, 2000,16(6): 1173- 1177.
  • 7Weinrich S L, Pruzan R, Ma L, et al. Reconstitution of human telomerase with thetemplate RNA component hTERT and the catalytic protein subnit hTERT[J]. NatGenet,1997,17(4):498-502.
  • 8Wu T C, Lin P, Hsu CP, et al. Loss of telomerase activity may be a potential favorableprognostic marker in lung carcinomas [J]. Lung Cancer, 2002,41 (2): 163 -169.
  • 9Nakayama J, Tahara H, Tahara E, et al. Telomerase activation by hTERT in human normalfibroblasts and hepatocellular carcinomas[J]. Nat Genet,1998,18(1) :65-68.
  • 10Kumak1 F, Kawal T, Hirol, et al. Telomerase activity of human telom-erase RNA componentand human telomerase reverse transcriptase in lung[J]. Human Pathology, 2001,32(2) : 188-194.

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