恶性肿瘤患者血清中透明质酸、Ⅳ型胶原和层粘蛋白的检测及临床意义

The determination and clinic signification of HA, Ⅳ.C and LN in patients with milignant tumors

观察恶性肿瘤患者血清中透明质酸 (HA)、Ⅳ型胶原 (Ⅳ C)及层粘蛋白 (LN)的变化及意义。应用放射免疫法检测 8种恶性肿瘤共 2 0 5例、健康人 31例血清样品中HA、Ⅳ C及LN的含量 (x—±s)。结果表明三种标志在恶性肿瘤组分别比相应对照明显升高 (P <0 0 5 )。其中肝癌组HA含量明显高于其它肿瘤组 (P <0 0 5 ) ;伴有复发或有转移者血清HA、及LN是参与恶性肿瘤生长、侵袭及转移的重要的细胞外基质分子 。

To study the change and significance of serum hyaluronic acid(HA).type collagen(Ⅳ.C) and Laminin(LN) in patients with milignant tumor. The contents of HA, Ⅳ.C and LN were measured by radioimmunoassay in 205 cases with eight kinds of milignance and 31 healthy subjects. ①The contents (X±S) of HA, Ⅳ.C and LN in all of malignant tumor groups were significantly higher than those in healthy controls respectively ( P <0.01). ②The serum HA content from liver cancer evidently increased than that of any others malignant groups.③The contents of HA,Ⅳ.C and LN in patients with recurrence or metastasis were obviously higher than that of non recurrence and non metastasis ( P <0.01).HA,Ⅳ.C and LN were much vital extracellular matrix (ECM) and played an importent role in growth,invasion and metastasis of tumors. The detection of HA,Ⅳ.C and LN has been proved to be a potential approach to mornitoring cancer patients.