影响正常脑^(18)F-FDG代谢数个因素的统计参数图分析

The analysis of several factors relevant to brain ~ 18F-FDG metabolism by using the statistical parameter mapping

目的 研究脑18F 脱氧葡萄糖 (FDG)代谢与剂量、血糖水平以及年龄等因素的关系。方法 应用cPET仪和脑统计参数地图法 (SPM) ,将 30例正常人脑cPET图像按18F FDG给药剂量、血糖水平和年龄为自变量 ,用SPM多元线形回归模型分析。结果 统计分析结果显示年龄、给药剂量和血糖水平都是影响18F FDG脑局部摄取的相关因素。随着给药剂量增加 ,正常人双侧扣带回、双侧颞下回以及小脑摄取增加 ,而随血糖升高双侧额叶、双侧顶叶、双侧中央前回以及小脑局部18F FDG摄取有下降趋势 ,全脑18F FDG摄取与年龄呈负相关。结论 给药剂量、血糖水平以及年龄等能量底物环境均为正常人脑18F FDG摄取的影响因素。

Objective To study the relationship of the regional brain ~ 18F-fluorodeoxyglucose (FDG) metabolism and aging process, the dosage of the imaging agent, the level of blood sugar to cerebral PET (cPET) image data by using statistical parameter mapping (SPM) software. Methods ~ 18F-FDG cPET imaging data acquired from 30 healthy volunteers were collected and analyzed with SPM by the multiple linear regression model designed with dosage of tracer, and blood sugar level as explaining variables and the ~ 18F-FDG accumulation as responding variables. Results It's showed that the age, dosage and sugar level were all related with the ~ 18F-FDG accumulation in the brain. The accumulation of the radiotracer in the brain areas like cingulate gyri, inferior temporal gyri of both sides and the cerebellum increased with the tracer dosage, and the blood sugar escalating and the ~ 18F-FDG uptake in the brain areas like frontal lobes, parietal lobes, precentral gyri of both sides and cerebellum decreased at the same time, and the aging process led to a pancephalic ~ 18F-FDG decrease. Conclusions The injection dosage, sugar level and the age are all related with accumulation of the ~ 18F-FDG, and the SPM software can be used to analyze the multiple factors relevant to cPET imaging data based on voxel level and so can explain the experimental results more correctly.