降压胶囊治疗老年高血压病患者(阴虚阳亢型)的临床研究

Clinical Study on Jiangya Capsule in Treating Hypertension of Aged Patients with Yin-Deficiency and Yang-Excess Syndrome

目的 :探讨降压胶囊对老年高血压病患者 (阴虚阳亢型 )的疗效和作用机理。方法 :老年高血压病患者 75例 ,随机分为治疗组 (5 0例 )和对照组 (2 5例 ) ,分别用降压胶囊和罗布麻胶囊治疗 ,并测定两组患者治疗前后血压、脑血流速度、血液流变学、血脂及血浆心钠素水平。结果 :治疗组总有效率 (82 % )显著优于对照组 (5 6 % ,P <0 0 5 ) ;在改善临床症状、提高脑血流速度、改善血液流变学指标及升高血浆心钠素水平方面均优于对照组 (P <0 0 5或P <0 0 1) ;总胆固醇含量治疗后较治疗前降低 (P <0 0 5 )。对照组仅血压较治疗前降低 (P <0 0 5 ) ,其余指标治疗前后比较差异均无显著性。结论 :降压胶囊对老年高血压病有较好的疗效 。

Objective: To study the effect and mechanism of Jiangya Capsule (JYC) in treating aged patients with hypertension. Methods: Patients were randomly divided into two groups, 50 in the treated group and 25 in the control group, they were treated with JYC and Herba Apocyni veneti (HAV) Capsule respectively. Blood pressure (BP), cerebral blood flow velocity, hemorrheological changes, blood lipid and plasma atrial natriuretic peptide (ANP) in both groups before and after treatment were determined. Results: The total effective rate in the treated group was 82%, which was significantly better than that in the control group (56%, P<0 05). The JYC treatment were superior to the control in all aspects, such as improving clinical symptoms, reducing velocity of cerebral blood flow, improving the hemorrheologic and blood lipid parameters and raising plasma ANP (P<0 05 or P<0 01). In the control group, effective changes only showed in reducing BP (P<0 05), no significant change of other parameters was noticed. Conclusion: JYC has good effect in treating hypertension, the mechanism is possibly related with its effect in raising plasma ANP.