中国人单通道多焦视诱发电位的可重复性研究

The study on reproducibility of single channel multifocal VEP in Chinese

目的 :探讨单通道多焦视诱发电位 (mVEP)在中国人应用的可重复性。方法 :应用VERIS多焦电生理系统对 7例受试者在非同一日记录单通道图形mVEP ,刺激图案为 6 0个扇面组成与大脑皮质成比例的飞镖盘样图形。用PhotoShop软件将mVEP曲线叠合分析mVEP波形的一致性 ,并用VERIS软件定量测量mVEP曲线主要波形的潜伏期、峰 谷振幅 ,数据采用Excel软件进行统计学分析。结果 :受试者自身不同时间的 2～ 7次检查得出的mVEP波形的叠合程度高 ,潜伏期变异系数 (CV)小于 10 % ,但振幅有一定程度的变异 ,6 0个位点曲线振幅的平均CV左、右眼分别为 36 %、37% ,象限平均反应曲线的振幅CV分别为 19%、2 1%、2 6 %、2 7% ,上、下半野平均反应曲线的振幅CV分别为 13%和 11%。结论 :单通道mVEP多位点反应波形的可重复性良好 ,但振幅存在一定程度的变异。当刺激与记录条件一致时 ,mVEP尤其是象限与半野平均反应可用于视神经损害程度的随访研究。

Objective:To investigate the reproducibility of single channel multifocal VEP in Chinese.Methods:We recorded single channel multifocal VEP from 7 subjects with VERIS TM Science on different occasions.The stimulus pattern consisted of 60 sectors cortically scaled like a dartboard.The mVEP's traces were superimposed with PhotoShop software and waveform consistency were analyzed.The latencies and peak-to-trough amplitudes of major waveform in mVEP were measured with VERIS TM Science software.The data were analyzed with Excel software.Result:The mVEP waveform recorded on different days had high consistency when superimposed.The latency's coefficient of variation (CV) was only 10% or less.However there were small variations of amplitude,which showed the average CVs of the amplitude in 60 location of left and right eye were 37% and 39%,respectively.The amplitude CVs of the average response in four quadrants were 19%,21%,26% and 27%,respectively.The amplitude CVs of the average response in upper and lower hemifield were 13% and 11%,respectively.Conclusion:The waveforms of single channel mVEP have good reproducibility,but the amplitudes with variability to some extent.When stimulus,electrodes and record parameters are consistent,mVEP can be used to track and follow up the degree of optic nerve impairment in patients.