摘要
为探讨理气补血汤对周围神经损伤功能恢复的影响 ,采用钳夹 SD大鼠坐骨神经的方法建立周围神经损伤的动物模型。将 6 6只造模大鼠随机分为实验组和对照组 ,每组再分为 2、4、6周 3个时间组 ,每日分别给予理气补血汤水煎剂和生理盐水灌胃。分别进行坐骨神经功能指数 (SFI)、神经电生理指标、小腿三头肌湿重的检测。结果显示 ,实验组 SD大鼠一般情况优于对照组 ;实验组的 SFI恢复率显著优于对照组 ;实验组运动神经诱发电位潜伏期的延迟率、复合肌肉动作电位振幅的恢复率、小腿三头肌单收缩力和强直收缩力的恢复率均优于对照组 ;小腿三头肌湿重的恢复率实验组显著高于对照组。表明理气补血汤可以促进周围神经损伤的修复再生 ,明显提高神经功能的恢复。
Objective: To investigate the effect of Liqi Buxue Decoction(LBD) on functional recovery of the injured peripheral nerve. Methods: Peripheral nerve injury model was set up by crushing the right sciatic nerve of rats. Sixty-six model Sprague Dawley rats were randomly divided into experimental group and control group and administered respectively with LBD and normal saline every day after surgery. All the indexes were tested in 2、4、6 weeks of operative intervals respectively. Results: The general observation in the experimental group was superior to that in the control group; The recovery rate of sciatic nerve functional index (SFI) was significantly higher in the experimental group than that in the control group; In the experimental group the delayed rate of induced motorius action potential, recovery rates of the amplitude of compound muscle action potential and twitch tension and tetanic tension of triceps musculus surae muscle were significantly higher than those in the control group; Compared with the control group ,the wet weight musculus triceps surae muscle was significantly greater in the experimental group. Conclusion: LBD can promote the injured peripheral nerve repair and regeneration and functional recovery.
出处
《中医正骨》
2002年第10期3-4,共2页
The Journal of Traditional Chinese Orthopedics and Traumatology
基金
福建省科技三项费用基金资助项目 编号 K2 0 0 66
