胎儿宫内发育迟缓孕妇血清和脐血甲状腺激素水平的相关性研究

A CORRELATIVE STUDY ON THE THYROXINE HORMONE LEVELS BETWEEN MATERNAL SERUM AND UMBILICUS BLOOD IN INTRAUTERINE GROWTH RETARDATION

目的 :探讨胎儿宫内发育迟缓 (IUGR)孕妇血清和脐血中甲状腺激素的变化。方法 :采用放射免疫分析法测定正常足月妊娠孕妇 6 2例 (对照组 )和 IUGR孕妇 2 4例 (IU GR组 )血清和脐血中甲状腺素 (T4 )、三碘甲状腺原氨酸 (T3)、游离 T3(FT3)、游离 T4 (FT4 )、促甲状腺素 (TSH)水平。结果 :IU GR组孕妇血清和脐血中 TSH高于对照组 (P <0 .0 5 ) ,脐血 T4 、 FT4 均明显下降 (P<0 .0 5 )。两组母血与脐血 T3、T4 、FT4 、TSH均呈正相关 (均 P<0 .0 5 )。结论 :IU GR发病原因与甲状腺激素水平低下有关 ,在妊娠期可以通过测定母血甲状腺功能 ,尽早对 IU GR做出诊断 ,使 IU GR在宫内得到及时、有效的治疗。

Objective:To investigate the relationship in the thyroxine hormone levels between maternal serum and umbilicus blood in intrauterine growth retardation (IUGR) Methods: The concentrations of triiodothyronine (T 3), thyroxine (T 4), thyroid stimulating hormone (TSH), free thyroxine (FT 4) and free triiodothyronine (FT 3) were tested in maternal serum and umbilicus blood The samples were collected from 24 term pregnancies with IUGR, and 62 normal pregnancies served as control T 4, T 3, FT 4, FT 3 and TSH by immunoradiometric assay (IRMA) technique Results: The T 4, FT 4 in umbilical blood was lower in IUGR group than that in the control group (P<0 05), the TSH level in umbilical blood was higher in IUGR than that in the control group (P<0 05) The T 3,T 4,FT 4,TSH levels in pregnant women were positively correlated with the cord blood T 3,T 4,FT 4,TSH levels of their new borns in both groups (all P <0 05) Conclusion: This study confirms previous observation that insufficiency of thyroidectomy might be a pathogenesis of IUGR