从表型到功能——p38α基因敲除小鼠的表型分析新进展

From Phenotype to Function:Analysis of Phenotype of p38α Knockout Mice

基因敲除技术的广泛应用 ,极大地推动了后基因组时代对于基因功能研究的进程 .近年来 ,对于有丝分裂原激活的蛋白激酶家族成员之一——— p38α的基因敲除小鼠的研究 ,在过滤“噪音” ,真实、清晰地揭示敲除基因的体内功能等方面极具典型意义 .对于其有关表型分析最新研究进展的回顾说明 :在精心设计及其表型的周密分析前提下 ,基因敲除技术的合理运用 ,对于全面阐释重要信号分子的体内功能 。

The widespread use of gene knockout technology promotes the course of the research of gene function in post genomic era greatly. Recently, the research of p 38 α knockout mice, which is one member of MAPKs, is very typical in filtering noise from critical signals in signal transduction and translating phenotype into gene function. Looking back on the research of p 38 α knockout mice showed: the reasonable use of gene knockout technology, based on carefully designed and analyzed mutant mice, is very important for defining the function in vivo of important signal molecular and pushing forward the research of function gene.