杆状病毒作为基因治疗载体的研究进展

The Development of Baculoviruses as Novel Gene Therapy Vectors

杆状病毒是昆虫专一性的病原病毒 .近来的研究表明杆状病毒能进入哺乳动物细胞 ,但病毒自身不能在哺乳动物细胞中复制 ,感染也不引起细胞病变 .另外 ,已经证明杆状病毒能在体外或体内高效地转导许多类型哺乳动物细胞 ,并且能得到固定表达细胞系 ,显示了杆状病毒作为基因治疗载体有着良好的应用前景 .

Baculoviruses are host specific for insects. The recent researches indicated that baculoviruses could entry into different mammalian cells, but do not replicate. The baculoviruses have been successfully used to deliver foreign DNA into mammalian cells in vitro and in vivo and efficiently mediated the expression of interest genes. These results indicated that baculovirus could be developed as potential gene therapy vectors. The recent development and prospects on using baculoviruses as target gene delivered vectors in gene therapy is reviewed.