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鼻腔免疫研究进展 被引量：1

Advances in the research of intranasal immunization
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摘要 鼻腔免疫能避免肝脏的首过效应,有效地诱导粘膜局部免疫和系统免疫应答,具有远端共同粘膜效应,比其它免疫途径更简便、更安全,成为当今疫苗研究的重点方向之一。本文综述鼻腔免疫应答的细胞和分子机理、抗原释放系统及佐剂等方面的最新研究进展。 Intranasal administration of antigen can avoid the first past of liver,induce local and systemic immuno-logical response potently,and have common mucosal effect.It's more convenient and safe compared with other vacci-nations,therefore had become one hotspot of current vaccinal developments.We summarize the recent advances of the cellular and molecular mechanism,the delivery system of antigen and adjuvant of intranasal immunization.
作者 李菁 胡云章
机构地区 中国医学科学院/中国协和医科大学医学生物学研究所
出处 《生物技术通讯》 CAS 2002年第6期476-478,482,共4页 Letters in Biotechnology
关键词 鼻腔免疫 研究进展 鼻相关淋巴组织 抗原释放系统 佐剂 intranasal immunization nasal-associated lymphoid tissue the delivery system of antigen adjuvant
分类号 R392.1 [医药卫生—免疫学] R186 [医药卫生—流行病学]
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参考文献26

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同被引文献18

  • 1杨志军,韦隆华,唐俊杰.麻疹疫苗及加佐剂经滴鼻免疫小鼠的抗体应答[J].贵阳医学院学报,2005,30(1):23-25. 被引量：2
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生物技术通讯
2002年 第6期

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