tau蛋白和载脂蛋白E对痴呆的诊断价值

The diagnostic value of tau protein and Apolipoprotein E in patients with Alzheimer′s disease and cerebrovascular disease

目的 探讨脑脊液tau蛋白和血清载脂蛋白E对痴呆的诊断价值。方法 2 6例Alzheimer病痴呆(Alzheimer′sdisease,AD)患者 ,2 4例血管性痴呆 (cerebrovasculardementiaVD)患者和 30例年龄相当无神经系统疾病者 (normalcontrol,NC) ,分别检测其脑脊液中tau (CSFtau)蛋白水平和载脂蛋白E (ApoE)基因型分布和等位基因频率。结果 3组被检者脑脊液中tau蛋白含量间的差别有显著性意义 (P <0 0 0 1) ;VD组和NC组tau蛋白含量间差别无显著性意义 (P >0 0 5 ) ,3组被检者ApoE基因型构成比间差别有显著性意义 (P <0 0 1)。AD和VD组的ApoE 2 / 4、ApoE 3/ 4与NC组的比较 ,其构成比间差别有显著性意义 (P <0 0 5 )。而AD和VD组ApoE 2 / 4 ,ApoE3/ 4构成比间差别无显著性意义 (P >0 0 5 )。 3组被检者ApoE等位基因E4频率间的差别有显著性意义 (P <0 0 1)。结论 CSF中的tau蛋白含量和血清ApoE 4频率及ApoE 3/ 4、ApoE 2 / 4基因型的检测有助于痴呆的早期诊断 。

Objective To investigate the diagnostic aid of tau protein in CSF and Apolipoprotein E(ApoE) in serum in various types of dementia including Alzheimer′s disease(AD) and cerebrovascular disease(VD).Methods Tau protein and ApoE levels were determined in 28 patients with Alzheimer′s disease(AD),22 patients with cerebrovascular disease(VD) and 30 age-matched normal controls.Results Significant difference was found among three groups(P<0 001),but neither AD group and NC group nor VD group and NC group showed statistic significance (P>0 05).Frequency of ApoE 2/4 and ApoE 3/4 occurrence in AD and VD group was significantly different from the NC group (P<0 05),but showed no statistic significance between AD and VD group.Frequency of ApoE 4 allele occurrence in three groups was significantly different (P<0 01),but showed no statistic significance between AD and VD group.Conclusion These findings suggest that AD and VD can be separated from normal by the frequency of ApoE2/4,ApoE3/4 and ApoE 4 allele.CSF-tau may provide a diagnostic aid in the differential diagnosis between VD and AD.