福尔马林致大鼠膀胱痛牵涉区的观测

THE REFERRED AREAS WERE OBSERVED AND DETERMINED IN THE RAT URINARY BLADDER PAIN BY FORMALIN STIMULI

目的 :研究大鼠膀胱致痛后牵涉区出现的所在部位 ,为探讨经牵涉区治疗内脏痛和阐明牵涉痛发生的机理提供实验和理论基础。方法 :SD大鼠 ,颈内静脉注入伊文思蓝染料 ,观察、比较动物在福尔马林致膀胱痛后该染料渗漏出现的部位。结果 :福尔马林致膀胱痛的动物伊文思蓝染料渗漏斑较恒定出现在耻骨联合腹侧局部皮区。结论 :根据牵涉痛发生机制的交感反射假说 ,初步认为大鼠膀胱痛所致牵涉区在耻骨联合腹侧皮肤。

Objective:To offer a groundwork for the treatment of viseral pain by referred area and mechanisms of referred pain by observing and determining the referred area in the rat urinary bladder pain by formalin stimunli.Methods:Evens blue was injected into internal jugular vein of SD rats and the skin regions of coloring matter extravasation after inducing urinary bladder pain by formalin stimuli were observe.Results:Evens blue extravasation spots were found invariablely in the skin region abdominal to pubic symphysialis in the rats of Formalin group and nothing was found in the control group.Conclusions:It was a referred area to the skin region abdominal to pubic symphysialis in the rat urinary bladder pain byformalin stimunli.