摘要
目的 :研究附子汤与芍药甘草汤合用的镇痛作用及其机制。方法 :采用福尔马林疼痛模型大鼠 ,观察药物的镇痛作用 ;采用冰醋酸致痛模型小鼠 ,测血清和脊髓中一氧化氮 (NO催化光度法 )、前列腺素E2 (PGE2 )的含量和超氧化物歧化酶 (SOD)活性 (紫外分光光度法 )。结果 :附子汤加芍药甘草汤能抑制福尔马林引起的I相及Ⅱ相疼痛 ,能显著降低冰醋酸疼痛模型小鼠血清中和脊髓中的NO ,PGE2 的含量 ,增加SOD的活性。结论 :附子汤与芍药甘草汤合用对中枢及外周神经末梢均有镇痛作用 ,其镇痛作用与NO ,PGE2 。
Objective: It is to investigate the analgesic functions and mechanism of monkshood decoction and decoction containing peony and licorice. Methods: The analgesic functions were observed with formalin painful model rats. Nitrous oxide (NO) in blood serum and spinal marrow (NO catalysis photometry), amount of prostaglandin E 2 (PGE 2) and activity of super oxide dismutase (SOD) were determined with ice acetic acid caused pain model mice. Results: The drug could inhibit pains in phase I and phase II resulted from formalin, it also could decrease the amount of NO and PGE 2 in blood serum and spinal marrow in ice acetic acid caused pain model mice and improve the activity of SOD. Conclusion: Monkshood decoction and decoction containing peony and licorice have analgesic functions on central and peripheral nerve endings, and the analgesic function are related to NO, PGE 2 and SOD.
出处
《现代中西医结合杂志》
CAS
2002年第23期2323-2325,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
附子汤
芍药甘草汤
镇痛作用
一氧化氮
前列腺素E2
超氧化物歧化酶
monkshood decoction decoction containing peony and licorice analgesic function nitrous oxide prostaglandin E 2 super oxide dismutase
