期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基质金属蛋白酶-2在子宫内膜异位症与子宫腺肌症中的表达及其意义 被引量：2

原文传递
导出
摘要 目的探讨基质金属蛋白酶 -2 ( MMP-2 )在子宫内膜异位症与子宫腺肌症发生、发展中的作用。方法应用免疫组织化学法 ( SABC法 ) ,检测 70例子宫内膜异位症与子宫腺肌症内膜组织 (异位内膜组 )和 3 0例正常子宫内膜组织 (对照组 )中 MMP-2的表达。结果MMP-2在异位内膜组其阳性表达率为 71.43 % ( 5 0 /70 ) ,对照组为 40 % ( 12 /3 0 ) ;强阳性表达率异位内膜组为 40 .0 0 % ( 2 8/70 ) ,对照组为 6.67% ( 2 /3 0 )。两组比较有显著性差异 ( P<0 .0 1)。 MMP-2在卵巢子宫内膜异位症和子宫腺肌症患者阳性表达率分别为69.44 % ( 2 5 /3 6)和 73 .5 3 % ( 2 5 /3 4) ;强阳性表达率分别为 3 3 .3 3 % ( 12 /3 6)和 47.0 6% ( 16/3 4) ,两者比较无显著性差异 ( P>0 .0 5 )。结论异位内膜组织中 MMP-2的过度表达与异位内膜组织的侵袭力有关 ,MMP-2在子宫内膜异位症的发生、发展中具有重要作用。而抑制 MMP-2可为子宫内膜异位症的治疗提供新的靶点。
作者 齐璇 辛晓燕 常吉庆 王德堂 郭会玲
机构地区 第四军医大学西京医院妇产科 第四军医大学西京医院病理科
出处 《中国综合临床》 北大核心 2002年第12期1130-1131,共2页 Clinical Medicine of China
关键词 子宫腺肌症 子宫内膜异位症 基质金属蛋白酶-2 明胶酶A 细胞外基质 免疫组织化学 EMS
分类号 R711.71 [医药卫生—妇产科学] R711 [医药卫生—妇产科学]
  • 相关文献

参考文献11

  • 1Bruner Tran KL,Rier SE,Eisenberg E,et al.The potential role of envir onmental toxins in the pathophysiology of endometriosis.Gynecol Obstet Invest,19 99,48(1):45-46
  • 2Sampson J.Peritoneal endometriosis due to mentraldissemination o f e ndometrial tissue into the peritoneal cavity.Am J Obster Gnecol,1997,14(7):422- 469
  • 3Sillem M,Hahn U,Coddington CC,et al.Ectopic growth ofendometrium d e pends on its structural integrity and proteolytic activity in the cynomolgus mon key (Macaca fascicularis) model of endometriosis.Fertil Steril,1996,66(3):468-4 773
  • 4Regidor PA,Vogel C,Regidodr M,et al. Expression pattern of intergrin adhesion molecules in endometriosis and human endometrium.Hum Reprod Update,199 8,4(2):710-718
  • 5Boyd RS,Balkwill FR.MMP-2 release and activation in ovarian carcino ma:the role of fibroblasts.Br J Cancer,1999,80(5):315-321
  • 6Bruner KL,Matrisian LM,Rodgers WH,et al.Suppression ofmatrix met all oproteinases inhibits establishment of ectopic lesions by human endometrium in n ude mice.J Clin Invest,1997,99(12):2851-2857
  • 7郭新华,娄艳辉.基质金属蛋白酶-1、2在异位内膜组织中的表达[J].现代妇产科进展,2001,10(5):356-358. 被引量：6
  • 8Wenzl RJ,Heinzl H.Localization of matrix metalloproteinase-2 in ute rine endometrium and ectopic implants.Gynecol Obstet Invest,1998,45(3):253-257
  • 9Ries C,Petrides PE,Cytokine regulation of matrix metallop-roteina ses activity and is regulatory dysfunction in disease.Biol Chem,1995,376(9):345-35 5
  • 10Rawdanowicy T,Hampton A.Matrix metalloproteinaseprod u ction by cultured human endometrial cells:identification of interstitial collage nase,gelatinase-A,gelatinase-B,and stromelysin-1 and tumor necrosis factor-2 .J Chin Endo Metab,1994,79(2):530-536

二级参考文献6

  • 1Sillem M,Hahn U,Coddington CC 3rd,et al.Ectopic growth of endometr ium depends on its structural integrity and proteolytic activty in the cynomolgu s monkey(Macaca fascicularis) model of endometriosis[J].Fertil Steril,1996,66( 3):468-73
  • 2Stetler-Stevenson WG,Aznavoorian S,Liotta LA.Tumor cell interacti o ns with the extracellular matrix duing invasion and metastasis[J].Annu Rev Cel l Biol,1993,9:541-73
  • 3Regidor PA,Vogel C,Regidodr M,et al.Expression pattern of intergri n adhesion molecules in endometriosis and human endometrium[J].Hum Reprod Upd at e,1998,4:710-718
  • 4Bruner KL,Matrisian LM,Rodgers WH,et al.Suppression of matrix meta lloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice[J].J Clin Invest,1997,99(12):2851-7
  • 5Spuijbroek MDEH,Dunselman GAJ,Menheere PPCA,et al.Early endometrio sis invades the extracellular matrix[J].Fertil Steril,1992,58:929-33
  • 6Wenzl RJ,Heinzl H.Localization of matrix metalloproteinase-2 in u t erine endometrium and ectopic implants[J].Gynecol Obstet Invest,1998,45:253-2 5 7

共引文献5

同被引文献21

  • 1Sampson J. Peritomeal endometriosis is due to the menstrual dissemination of endometrial tissue into the peritoneal cavitity[J].Am J Obstet Gynecol, 1927,14(4): 422- 469.
  • 2Halme J, Hammond M G, Hulka J F, et al. Retrograde menstruation in healthy women and in patient with endometriosis[J]. Obstst Gynecol, 1984,64(2):151 154.
  • 3Sillem M, priftis, Koch A, et al. Regulation of matrix metalloproteinases and their inhibitor in uterine endometrial cells of patients with and without endomtriosis. Eur J Obstet Gynecol[J].Reprod Biol, 2001,95(2): 167- 174.
  • 4Chung H W, Wen Y, Chun S H, et al. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 mRNA expression in ectopic and eutopic endometriotic in vasiveness[J]. Fertil Steril, 2001,75(1) :152-159.
  • 5Cox K E. Differential regulation of matrix metalloproteinase-3gene expression in endometriotic lesions compared with endometrium[J]. Biol Reprod, 2001, 65(4) : 1297- 1303.
  • 6Witz C A, Monotoya-Rodriguez I A, Schenken R S. Whole explants of peritoneum and endometrium: a novel model of the early endometriosis lesion[J]. Fetil Steril, 1999,71(1): 56-60.
  • 7Brew K,Dinakarpandian D, Nagase H. Tissue inhibitors of metalloproteinases :evolution, structure and function[J]. Biochim Biophys Acta, 2000, 1477( 1 - 2): 267- 283.
  • 8Huhtala P, Chowl T, Tryggvason K. Structure of the human typeⅣcol lagenasegene[J]. J Biol Chem, 1990, 265 (19):11077 11082.
  • 9Soini Y, Alarakkola E, AutioHarmainen H. Expression of messenger RNA for etalloproteinases[J]. Hum Pathol, 1997,28 (2):220-224.
  • 10Rodgers W H, Matrision L M,Giudice, et al. Patterns of matrix metalloproteinases expression in cycling endometrium imply differential function and regulation by steroid hormones[J]. J Clin Invest, 1994,94(3) :946-953.

引证文献2

二级引证文献3

中国综合临床
2002年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部