甘露聚糖结合凝集素的生物学功能及其临床意义

Relationship between the function of mannan-binding lectin and disease

甘露聚糖结合凝集素 (MBL)是一种肝源性的血清蛋白 ,属Ca2 + 依赖型凝集素家族成员 ,在天然免疫中起重要作用。MBL具有调理功能 ,可选择性结合表面富含甘露寡糖的病原体 ,既可通过MBL途径活化补体 ,也可特异性结合细胞表面受体活化巨噬细胞。已发现MBL基因突变可致血清MBL水平低下和功能缺损。MBL缺损使个体易患某些感染性疾病和自身免疫病。

Mannan binding lectin (MBL) is a serum protein of hepatic origin belonging to a family of Ca 2+ dependent collagenous lectins and plays an important role in innate immunity. MBL may act as an opsonin activating complement through binding selectively to mannan rich pathogens and also activates macrophages via recognizing specific cell receptors. It is found that MBL gene mutations may induce low serum concentration and functional defect of MBL. The individuals with MBL deficiency are susceptible to some infections and autoimmune diseases.