吸一氧化氮或氧对高原健康人和高原肺水肿患者血氧饱和度及心率的影响

Effect of Inhaling Nitric Oxide or Oxygen on Blood Oxygen Saturation and Heart Rate in High Altitude Pulmonary Edema

目的 研究吸一氧化氮(NO)或氧(O2)对高原健康人和高原肺水肿患者血氧饱和度(SaO2)及心率(HR)的影响。方法 高原健康士兵20名及高原肺水肿患者24名,随机各分为两组,每组10人和12人。一组分别吸入0.001％(10PPm)NO,另一组分别吸O2,吸入气O2含量均为80％,结果 高原健康人吸NO或O2后及高原肺水肿患者吸NO后SaO2明显增高(P<0.01);高原健康人吸NO10-30min及吸后3-5min和高原肺水肿患者吸NO20-30min及吸后3-5min HR明显降低(P<0.01),吸氧后改变不明显(P>0.05)。结论 吸入低浓度NO可明显提高高原健康人和高原肺水肿患者的SaO2及降低HR,改善其心肺功能。

Objective To study the effect of inhaling nitric oxide(NO)or oxygen (O2) on blood oxygen saturation ( SaO2) and heart rate ( HR )in high altitude pulmonary edema ( HAPE). Methods In the clinic at 3700m altitude, 12 cases of HAPE were treated with low concentration ( 0.001%) NO gas mixture inhalation ( NO group )in addition to routine treatment and other 12 cases of HAPE were treatment with inhaling O2(O2 group ) on the basis of routine treatment, and compared with 20 health subjects ( Control group ). Resuits The SaO2 were significantly increased both in NO group and control group (P<0.01), as compared with health subjects who inhaling O2 for 10 ~30 minutes the HR were significantly decreased in patients and those subjects inhaling NO ( P<0.01 ). Conclusion NO inhalation could increased SaO2 anddecreased HR in HAPE patients and those health youth.