扩张型心肌病心肌细胞外基质重塑机制研究

Investigation of the mechanism of extracellular matrix remodelling in patients with dilated cardiomyopathy.

目的:探讨原发性扩张型心肌病心肌细胞外基质重塑机制。方法:采用放射免疫方法测定原发性扩张型心肌病35例和24例正常对照组心肌细胞外基质血清学指标:Ⅲ型前胶原(PCⅢ)、层粘连蛋白(LN)、透明质酸(HA)以及血浆血管紧张素Ⅱ(AngⅡ)及醛固酮(ALD)含量,将AngⅡ、ALD分别与PCⅢ、LN、HA进行相关分析。结果:原发性扩张型心肌病血浆AngⅡ、ALD浓度明显增高,AngⅡ、ALD分别与PcⅢ、LN、HA密切相关。结论:原发性扩张型心肌病AngⅡ、ALD分泌明显过多,在心肌细胞外基质重塑过程中起着重要作用。

Objective: To investigate the mechanism of extracellular matrix(ECM) remodelling in patients with dilated cardiomyopathy. Methods: The concentrations of serum procollagen type Ⅲ (PC Ⅲ), laminin(LN), hyaluronic(HA) as well as plasma angiotension Ⅱ (Ang Ⅱ )and aldosterone(ALD)were measured by radioimmunoassay in 35 cases of primary dilated cardiomyopathy and 24 normal persons as control. The correlations were analysed between plasma levels of angiotension Ⅱ , aldos-terone and serum indices of ECM. Results: Compared with normal controls, the concentrations of plasma angiotension Ⅱ and aldosterone were significantly increased in primary dilated cardiomyopathy, angiotension Ⅱ positively correlated with indices of ECM,and so did afdosterone.Conclusion:Our results suggest that angiotension Ⅱ and aldosterone play important roles in ECM remodelling.