摘要
目的 探讨急性白血病 (AL)患者血清白细胞介素 - 2 (IL- 2 )及血液 T细胞亚群水平。方法 采用酶联免疫吸附试验 (EL ISA)及荧光免疫法测定 30例急性白血病患者白细胞介素 - 2及血液 T细胞亚群水平 ,并与对照组比较。结果 AL患者 IL - 2含量显著低于对照组 (P<0 .0 1) ,T细胞亚群中 CD3+ 、CD4 + 均低于对照组水平 (P<0 .0 1) ,CD8+ 高于对照组水平 (P>0 .0 5 ) ,经治疗缓解患者 IL- 2、CD3+、CD4 +、CD8+达正常水平。结论 IL- 2和 T细胞亚群可作为 AL 辅助诊断指标 ,为临床治疗提供实验依据。
Objective To study the changes of serum interleukin 2(IL 2) and blood T cell subsets levels in acute leukaemia(AL) patients.Methods The changes of IL 2 and T cell subsetss levels in 30 AL patients were determined by ELISA and fluorescent immunological method,and the comparison between the results of patients and controlled group was also made.Results The IL 2 levels was significantly lower in patients than those in control group (P<0.01),and it was true of CD 3 +and CD 4 + of T cell subsets (P<0.01), while CD 8 + levels were higher than those in control group (P>0.05).The levels of IL 2,CD 4 +,CD 8+ T cells of the improved patients after therapy reached normal levels.Conclusion IL 2 and T cell subsets could be used as the assistant index of diagnosis,and provide experimental basis for the clinic therapy for AL.
出处
《中国误诊学杂志》
CAS
2002年第12期1787-1788,共2页
Chinese Journal of Misdiagnostics