调压益心胶囊治疗老年收缩期高血压50例疗效观察

Therapeutic effect of Tiaoya Yixin capsule(调压益心胶囊)on 50 cases of senile isolated systolic hypertension

目的 :研究调压益心胶囊对老年收缩期高血压 (ISH)的影响及其可能机制。方法 :80例 ISH患者随机分为调压益心胶囊治疗组 5 0例和卡托普利对照组 30例 ,进行服药前后的临床疗效观察。结果 :治疗组总有效率为 90 .0 0 % ,对照组总有效率为 93.33% ,2组比较无显著性差异 (P>0 .0 5 ) ;但 2组显效率比较 ,治疗组(6 4 .0 0 % )明显优于对照组 (43.33% ,P<0 .0 5 )。2组超声心动图左室肥厚 (L VH)有关指标治疗前后比较 ,大都有明显差异 (P<0 .0 5或 P<0 .0 1)。另外 ,在改善左室舒张功能和血脂异常方面 ,治疗组亦明显优于对照组。结论 :调压益心胶囊和卡托普利对 ISH和 L VH均有显著的调控和逆转作用 ;

Objective:To assess the effect of Tiaoya Yixin capsule(TYYXC,调压益心胶囊) in treating senile isolated systolic hypertension (ISH). Methods:Eighty patients with senile ISH were randomly divided into two groups. Treatment group were treated with TYYXC ( n =50),control group with captopril ( n =30). Therapeutic effect in before and after treatment was analysised.Results:The total effective rate in treatment group was 90 00% and control group was 93 33%,there were no obvious difference between two groups ( P >0 05). But the markedly effective rate in treatment group(64 00%) were much better in the control group (43 33%, P <0 05).After treatment there were significant reduction of left ventricular mass index (LVMI) and improvement of left ventricular dysfunction in both groups ( P <0 05 or P <0 01).The improvement of left ventricular diastolic function and dyslipidemias indexes in treatment group was much better than control group ( P <0 05 or P <0 01).Conclusions: Both TYYXC and captopril are effective in the treatment of senile ISH and in the reversal of left ventricular hypertrophy . TYYXC can also enchance the left ventricular diastolic function and showed benificial effect on dyslipidemias.