培哚普利长期治疗对充血性心力衰竭患者血清细胞因子水平的影响

Effect of Long Term Perindopril Treatment on Serum TNF-α,IL-6 in Congestive Heart Failure

目的 探讨长期使用培哚普利治疗充血性心力衰竭 (CHF)患者后血清细胞因子水平变化的意义。方法 选择长期或短期使用培哚普利的缺血性与高血压性CHF患者各 32例、30例 ,正常对照组 30例 ,测定血清肿瘤坏死因子(TNF α)、白细胞介素 - 6 (IL 6 )水平并作比较。结果 CHF患者血清TNF α、IL 6水平明显高于正常对照组 (P <0 0 1) ,CHF长期使用培哚普利组TNF α、IL 6水平低于短期组 (P <0 0 5 )。结论 培哚普利可能直接或间接降低血清TNF α、IL 6水平 。

Objective To study the long term effect of perindopril treatment on serum TNF α?IL 6 level in patients with congestive heart failure caused by ischemic and hypertension. Method Serum level of TNF α?IL 6 were measured in controls ,CHF patients after long term( n =32) and short term ( n =30 ) treatment with perindopril. Results Serum level of TNF α?IL 6 in CHF patients were significantly higher than that of controls. Long term perindopril treatment decreased the serum level of TNF α?IL 6 significantly more than after short term treatment. Conclusion Perindopril decrease serum TNF α,IL 6 level in patients of congestive heart failure which may be beneficial to the remodeling of left ventricle.