神经肽Y在肾脏疾病中变化的临床研究

Relation between Plasma Level of Neuropeptide-Y and Chronic Renal Failure

目的 探讨神经肽Y (neuropeptidY ,NPY)在肾脏疾病中变化的临床意义。 方法 慢性肾功能衰竭组(CRF) 2 8例 ;肾病综合征组 (NS) 2 1例 ;正常对照组 2 5例 ,应用放射免疫法测定血浆NPY。结果 CRF组NPY含量显著高于NS组及正常对照组 (P <0 .0 1) ,NS组显著高于正常对照组 (P <0 .0 1) ,NPY与血尿素氮、肌酐、尿白蛋白呈显著正相关 (r =0 .4 4 31;0 .5 0 5 5 ;0 .2 918;P <0 .0 0 5 ,0 .0 5 ) ,与内生肌酐清除率呈显著负相关 (r=- 0 .36 17,P <0 .0 1)。结论 NPY在慢性肾功能衰竭及肾病综合征的发病机制中起一定作用 。

Objective To investigate the clinical significant of plasma level of neuropeptide Y(NPY) in chronic renal failure (CRF).Methods Plasma NPY was measured with radioimmunoassay in CRF patients ( n =28),nephritic syndrome(NS) patients ( n =21)and the normal control( n =25).Results There was a significant elevation of plasma NPY level in CRF and NS patients as compared with that in the normal control( P <0.01).The elevated level of plasma NPY in CRF and NS patients had positive relationship with level of blood urea nitrogen(BUN),serum creatinine(Scr) and ureomicroalbumin(MA)( P <0.005,<0.05). There was a negative relationship between the level of plasma NPY and endogenous creatinine clearance(Ccr)( P <0,01).Conclusion NPY may play an important role in the pathogenesis of CRF and NS and was strongly related with the severity of renal function damage.