不同药物硬膜外注射治疗腰椎间盘突出症疗效观察

THE TREATMENT OF LUMBAR INTERVERTEBRAL DISK HERNIA BY PERIDURAL INJECTION OF DIFFERENT MEDICINES: A Therapeutic-effect Observation

为了探讨不同药物硬膜外注射治疗腰椎间盘突出症的临床疗效 ,采用随机分组的方法将 181例腰椎间盘突出症患者分为3组 ,分别采用醋酸曲安奈德加利多卡因、醋酸曲安奈德加利多卡因再加透明质酸钠和单纯应用胶原酶行硬膜外注射治疗 ,结果显示三种治疗方法分别对腰椎间盘膨出或椎间盘突出 <0 .5cm、椎间盘突出或手术后导致的腰椎管狭窄、神经根粘连和椎间盘突出≥ 0 .5cm或髓核已破裂而引起的腰腿痛症状皆有明显疗效 (P <0 .0 5 )。表明 3组药物治疗腰椎间盘突出症机理不同 ,但均有良好疗效。

The aim of this paper is to explore the therapeutic effect of peridural injection of different medicines on lumbar intervertebral disk hernia (LIDH). One hundred and eighty-one cases of LIDH were randomly divided into three groups, which were treated by peridural injection of Triamcinolone Acetonide Acetate plus Lidocaine (Group One), Triamcinolone Acetonide Acetate plus Lidocaine and Sodium Hyaluronate (Group Two), and alone Collagen Enzyme (Group Three), respectively. The results showed that the three treatment methods could produce significant therapeutic effects on lumbar intervertebral disk hernia or bulge < 0.5 cm, lumbar spinal canal stenosis caused by surgery or LIDH, nerve-root adhesion, and lumbago and scelalgia caused by LIDH ≧0.5 cm or pulpiform nucleus rupture (P > 0.05), suggesting that all of the three pharmacotherapies could produce good therapeutic effects on LIDH in spite of their different mechanisms.