不同肝功能分级肝硬化患者的食管压力测定

ESOPHAGEAL MANOMETRY IN HEPATIC CIRRHOSIS WITH DIFFERENT LIVER FUNCTION GRADES

为了解不同肝功能分级肝硬化患者食管蠕动功能和食管压力变化的特点 ,选择肝硬化患者 (肝硬化组 ) 94例 ,均经临床或病理确诊为肝硬化且有食管静脉曲张 ,肝功能Child分级 :A级 38例 ,有 8例伴发腹水 ;B级 37例 ,有 2 0例伴发腹水 ;C级 19例 ,有 18例伴发腹水。另选择无肝硬化的正常对照 (正常对照组 ) 72例 ,均无消化系统疾病及胃肠道症状 ,无腹部手术、外伤史。检查前 7天停用所有影响胃肠动力的药物。采用美国Sandhill公司Biolab食管动力检测系统及配套分析软件。结果显示 ,肝硬化肝功能A～C级各组食管下段括约肌静息压依次降低 ,松弛压力增大 ,松弛率变小 ;肝硬化组食管上段蠕动波起始点速度变慢 ,蠕动性收缩减少 ,异常收缩增加 ;肝硬化肝功能A～C级各组食管体部下段蠕动压力幅值依次降低 ,蠕动波起始点速度变慢 ,蠕动性收缩减少 ,异常收缩增加。以上结果表明 ,肝硬化患者肝功能损害越重 ,对食管正常动力影响越大 ,同时肝硬化患者食管静脉曲张与腹水形成亦有协同作用。

To measure esophageal manometric parameters in liver cirrhosis, patients with different liver function grades were chosen. In the normal control group ( n =72) gastrointestinal disease history and symptoms, abdominal surgery and injury history were all negative. In liver cirrhosis group ( n =94) liver cirrhosis was diagnosed by clinical picture or pathology, and their liver function in Child grade was: grade A, 38 cases and 8 had ascites; grade B, 37 cases and 20 had ascites; grade C, 19 cases and 18 had ascites. Taking no motility medicines within seven days before measurement, esophageal motility parameters of these subjects were taken by a Biolab System made by Sandhill Company. The data were analyzed with SAS statistical software. The results showed that from Child grade A to C, LESP in cirrhosis group reduced, relaxation pressure increased, and relaxation percentage become lower successively; from Child grade A to C, onset peristaltic wave velocity in upper esophageal body became slower, peristaltic contraction reduced, and abnormal contraction increased; from Child grade A to C, peristaltic wave amplitude reduced in lower esophageal body, and velocity of onset peristaltic wave velocity became slower, peristaltic contraction reduced, and abnormal contraction increased. It suggests that more severe injury in liver function, more serious impact in esophageal motility. At the same time complications of portal vein hypertention such as esophageal varices and ascites behave synergetically.