血浆心钠素与多普勒超声心动图检测左室舒张功能的对比研究

RELATIONSHIP BETWEEN PLASMA LEVEL OF ANP AND DOPPLER ECHOCARDIOGRAPHY PARAMETERS IN PATIENTS WITH LEFT VENTRICULAR DIASTOLIC DYSFUNCTION

探讨血浆心钠素浓度与多普勒超声心动图检测的左室舒张功能改变的相互关系。用二维、M型和多普勒超声获得心脏各腔室径、容量及二尖瓣、肺静脉血流多普勒参数 ,根据二尖瓣与肺静脉血流多普勒参数将 86例冠心病、高血压病人按左室舒张功能受损程度分类。同时用放免法检测血浆心钠素水平。结果发现 ,左室舒张功能受损后血浆心钠素水平明显升高 ,其浓度水平与左室舒张功能受损程度成正比 ;血浆心钠素水平与反映左室舒张功能的心脏超声指标LAD、E/A、IVRT、DT、AT、S/D及其相关指标LVDd、LVDs、EDV、ESV、LVEF、LVFS明显相关。提示血浆心钠素浓度可作为评价左室舒张功能受损程度的一个有意义的指标。

To investigate the relationship between the level of plasma atrial natriuretic peptides(ANP) and doppler echocardiography parameters in patients with left ventricular diastolic dysfunction, the patients were divided into four groups according to echocardiography parameters and their plasma levels of ANP, which were determined simultaneously.The results showed that along with left ventricular diastolic function was impaired, the level of ANP increased.There were significant relationships between the level of ANP and LAD, E/A, LVDd, LVDs, EDV, ESV, IVRT, DT, S/D, LVEF, LVFS, except for Pva and Pva dur. The results of this study suggest that the level of plasma ANP is a reliable marker of left ventricular diastolic dysfunction.