美多心安的制备及美多心安-β-环糊精包合物的验证

Preparation of Metoprolol and Confirmation of Inclusion Compound of Metoprolol-β-Cyclodextrin

通过共沉淀法制备了美多心安 -β-环糊精包合物 ,使用差热分析和核磁共振等方法加以鉴定 ,证实了美多心安 -β-环糊精包合物的形成 ,从而说明

The inclusion compound of Metoprolol-β-cyclodextrin is prepared by the co-precipitation method. Differential scanning calorimetric analysis and nuclear magnetic resonance prove the formation of the inclusion compound . The inclusion complex can be formed by β-cyclodextrin and water solubles.