摘要
目的 :研究高血压及高血压合并糖尿病患者血浆中甘油三酯 (TG)与小而密低密度脂蛋白 (SdLDL)的变化规律及洛伐他汀调脂药物对其的干预效果。 方法 :按照 1 999年世界卫生组织 (WHO) /国际高血压联盟 (ISH)高血压的标准入选 1 32例高血压患者 ,其中高血压无合并症 58例 ,高血压伴糖尿病 74例 ,根据TG水平分为TG正常组 (TG <1 7mmol/L ,n =52 ) ,TG增高组 (TG≥ 1 7mmol/L ,n =80 )。对上述患者进行每日洛伐他汀 2 0mg治疗 ,共 8周。治疗前后进行血脂 5个组分的测定。 结果 :①所有高血压患者TG增高组SdLDL及TG值均明显高于TG正常组 (P <0 0 5~ 0 0 1 ) ,高密度脂蛋白胆固醇(HDL C)低于TG正常组 (P <0 0 1 ) ,均有显著差异。两组中TC及低密度脂蛋白胆固醇 (LDL C)无差异。②洛伐他汀可使高血压合并糖尿病TG增高组患者各指标与治疗前相比均具有显著差异 (P <0 0 5~ 0 0 1 )。③高血压合并糖尿病患者中 ,治疗前TG增高组的SdLDL及TG值增高的程序明显高于单纯高血压患者的TG正常组 ,TG增高组SdLDL的增高与TG的升高呈正相关 (γ =0 4 2 ,P <0 0 5)。 结论 :高血压患者中 ,当TG≥ 1 7mnol/L时 ,其SdLDL呈增高趋势 ,高血压合并糖尿病者TG水平明显高于正常值 ,并伴有相关的SdLDL的增高。
Objective:To investigate the changes of triglycerin(TG)and small dense low density lipoprotein(SdLDL)in hypertension and diabetes,and to evaluate the effects of lovatatin. Methods:One hundred thirty tow hypertensive patients were selected according to the 1999 WHO/ISH Guidelines for the management of hypertension,in whom there were 58 patients with hypertension only and 74 with hypertension and diabetes.The patients were divided into group A(TG<1 7 mmol/L)and group B(TG≥1 7 mmol/L).The indexes of cholesterol(TC),SdLDL,TG,high density lipoprotein cholesterol(HDL C)and low density lipoprotein cholesterol(LDL C)were obtained before and after lovastatin treatment(20 mg daily). Results:①In those of group B SdLDL and TG values were significantly higher than those of group A,but HDL C was obviously lower than that of group A,(p<0 05).There werent any differences of TC and LDL C between groups.②In group B,TG,LDL C and SdLDL decreased significantly(0 6 mmol/L,0 66 mml/L and 0 66 mmol/L,respectively)after lovastatin treatment.③In patients with hypertension and diabetes,SdLDL was in normal range in group A and elevated obviously in group B. Conclusion:SdLDL had increased tendency in patients with hypertension and elevated TG(>1 7 mmol/L).TG increased significantly in patients with hypertension and diabetes accompanied by elevated SdLDL.Lovastatin can correct the plasma lipid disturbance in these patients.
出处
《中国循环杂志》
CSCD
北大核心
2002年第5期364-366,共3页
Chinese Circulation Journal