超敏TSH与TRH兴奋试验对亚临床甲功的诊断价值

The Diagnostic Effects of s-TSH and TRH Stimulating Test on Subclinical Thyroid Function

探讨超敏TSH(s -TSH)在单次检测与通过TRH兴奋试验动态变化对亚临床甲功的诊断价值。对 90例不同甲状腺疾病患者和 5 8名正常人进行TRH兴奋试验。5 8名对照组的s -TSH基础值为 2 .2 0± 1.85mIU/L ;亚临床甲亢组和亚临床甲减组的s-TSH基础值分别为 0 .5 4± 0 .3mIU/L与 9.0 8± 6 .3mIU/L ,此两组与对照组比较均有显著性差异 (P <0 .0 1) ,并发现单次测定s -TSH结果在甲亢患者与对照组之间有 15 %的交叉 ;正常生育期女性TRH兴奋试验表明 ,出现△s -TSH >30mIU/L。动态观察TRH兴奋试验结果比单次测定s -TSH结果更有助于亚临床甲功的诊断。

The study was carried out to investigate the diagnostic effects of supersensitive TSH on diagnosing subclinical thyroid function with only once s-TSH detection and with TRH stimulating tests. TRH stimulating tests have been undertaken for 90 patients with different thyroid disease and 58 normal subjects. Diagnostic basal levels of s-TSH test in control group, subclinical hyperthyroidism group and subclinical hypothyroidism group were 2.20±1.85mIU/L , 0.54±0.3mIU/L and 9.08±6.3mIU/L , respectively, the levels of subclinical hyperthyroidism and subclinical hypothyroidism group were significantly higher than that of normal subjects group ( P <0.01).We also have discovered that there was 15% intercross between hyperthyroidism group and control group in results of only once s-TSH test. In normal women's TRH stimulating tests, △s-TSH>30mIU/L. Dynamic observing of TRH stimulating tests have more effect than that of only once s-TSH detection in diagnosing subclinical thyroid function.