摘要
为探讨血清HA、PCⅢ、Ⅳ -C和LN水平对诊断肝纤维化的临床价值 ,对 180例慢性肝病患者分别采用RIA测定血清HA、PCⅢ、Ⅳ -C和LN水平。结果表明 ,血清HA、PCⅢ、Ⅳ -C和LN水平在慢性肝炎中度、重度及肝硬化患者明显高于对照组 (P <0 .0 5 ) ,且随着肝脏炎症和纤维化程度的加重而升高。结论是血清HA、PCⅢ、Ⅳ -C和LN水平可反映肝纤维化程度 ,四项联合检测是判断肝纤维化和早期肝硬化的无创伤性的、相对灵敏的指标。
To evaluate the diagnostic value of serum hyaluronic acid(HA),type Ⅲ procollagen(PCⅢ), typeⅣcollagen(IV-C)and laminin(LN)for hepatofibrosis, these 4 serum components were measured by RIA in 180 cases with chronic liver disease. The serum levels of HA, PCⅢ,Ⅳ-C and LN in chronic hepatitis and cirrhosis patients were significantly higher than those in the control group( P <0.05)and increased with the development of hepatitis and fibrosis. These items could reflect the degree of hepatic fibrosis and might be the indicators of hepatic cirrhosis in early stage.
出处
《标记免疫分析与临床》
CAS
2002年第4期207-208,共2页
Labeled Immunoassays and Clinical Medicine
