醒脑静合生脉注射液对脑出血急性期D-DIMER、ET-1的影响

The Effect of Xingnaojing-Shengmai Injection on D-Dimer and ET-1 in Patients of Intracerebral Hemorrhage(ICH) Acute Phase

目的:观察醒脑静合生脉注射液对脑出血急性期患者D-二聚体(D-DIMER)、内皮素(ET-1)的影响。方法:分别用ELISA法测定患者治疗前后外周血D-DIMER、ET-1水平。结果:醒脑静合生脉注射液能显著降低患者的D-DIMER、ET-1水平,改善程度明显优于醒脑静组(P<0.05)。结论:改善脑出血后全身的纤溶状态,保护损伤的脑实质,阻止脑出血后的继发性损伤;抑制脑出血后脑血管的痉挛,改善脑组织的缺血缺氧状态,可能是醒脑静合生脉注射液发挥临床疗效的途径之一。

Objective:To observe the effect of Xingnaojing-Shengmai injection on D-Dimer and ET-1 in patient of intracerebral hemorrhage(ICH) acute phase. Methods: ELISA was used to measure the level of D-Dimer and ET-1 in patient's peripheral blood before and after treatment. Results: The levels of D-Dimer and ET-1 in the patients were remarkably reduced by Xingnaojing-Shengmai injection, and the extent was better than that of Xingnaojing (P<0.05). Conclusion: It may be one of the ways that Xingnaojing-Shengmai injection play a curable role to improve the whole body's fibrinolysis and protect the damaged brain from the secondary lesion, to inhibit the convulsion of the blood vessels on the brain and improve the hypoxia-ischemia of the brain after ICH.