生长抑素在乳腺癌中的表达及其与DNA倍体的关系

Relationship between expression of somatostatin and DNA ploidy in breast cancer

目的 :探讨生长抑素 (SS)与乳腺癌的病理类型、雌激素受体 (ER)及肿瘤细胞核DNA倍体的关系。方法 :采用免疫组化链霉菌抗生物素蛋白过氧化物酶法 ,检测了 67例原发性乳腺癌及 2 5例乳腺良性肿瘤 ,并随机抽取 2 6例乳腺癌标本进行流式细胞术分析。结果 :生长抑素在恶性程度低的乳腺癌中的表达显著高于恶性程度高的乳癌 (P <0 0 5)。生长抑素表达阳性的乳癌多为二倍体癌 ,表达阴性者多为异倍体癌 ,两组间有显著性差异 (P <0 0 5)。结论 :生长抑素可延缓乳腺癌的发展 。

AIM: To investigate the relationship between somatostatin and the pathologic type, estrogen receptor,DNA ploidy of nuclei in tumor cells of breast cancer.METHODS: 67 cases of primary breast cancer and 25 cases of benign breast tumor were examined by immunohistochemical stretomyces avidin peroxidase method. 26 cases of breast cancer selected at random were analyzed by flow cytometry.RESULTS: Somatostatin expressed significantly higher in low malignant breast cancer than that in high malignant breast cancer ( P<0 05 ). Most of cancers with positive staining of somatostatin were diploidy,most of cancers with negative staining were aneuploidy,there had significant difference between two groups ( P<0 05 ).CONCLUSION: Somatostatin may delay the progress of breast cancer,and somatostatin levels in cancer tissues may become a useful indicator for assessing prognosis of patients with breast cancer.