CPP/PLLA软骨组织工程支架复合材料初步研究

CPP/PLLA COMPOSITES OF SCAFFOLDS FOR TISSUE ENGINEERING

采用溶媒投放、颗粒滤取技术制备出CPP/PLLA软骨组织工程支架复合材料,测试了该复合材料的物理力学性能和降解性能。研究结果表明,CPP/PLLA软骨组织工程支架复合材料具有高的孔隙率(90%)、良好的生物降解性能和物理力学性能,以及三维连通、微孔、网状微观结构,故该复合材料有希望成为软骨组织工程支架材料之一。

The CPP/PLLA composites of the scaffold for cartilage tissue engineering were fabricated with a solventcasting, particulateleaching method. Their properties of physical mechanics and degradation rates in vitro (in hank's at 37℃) were measured. The experimental results show that the composites have high porosity(ε=90%), good biodegradability and compressive modulus (8.6 GPa) as well as the 3D ,connectivity network microstructures. Therefore, this composites might be one of cartilage scaffold materials for tissue engineering with potentially broad applicability.