124例178份茶硷血药浓度监测结果分析

Result Analysis of 178 Serum Samples of 124 Patients Blood Concentration of Theopbylline

目的:回顾124例178份血清茶碱浓度结果,了解不同年龄段、血氧分压、联合激素、β_2受体激动剂对茶碱血清浓度影响。方法:在协议处方下给普通剂型茶碱,治疗过程监测茶碱血药浓度。结果:61～77岁老年人血清茶碱浓度,心血管毒副作用高于14～60岁的病人(P<0.01);血氧分压影响茶碱血药浓度,血氧分压越低,茶碱血清浓度有潴留倾向;联合激素、β_2受体激动剂对茶碱血药浓度无影响。结论:据病情个体化选择茶碱剂量剂型,有条件者注意监测血清茶碱血药浓度。单一的茶碱剂量增加产生毒副作用征象时应联合其它平喘药,以最大限度地降低茶碱毒副反应,产生较佳血药浓度。

Purpose;Retrospective analysis of 178 blood smaples of 124 patients,to find out the effect of age,blood oxygen pressure ( P02 ) , and combine administration of steroid hormone and β(J2 - receptor stimulant on the blood level of theophylline. Methods: Common -dosage form of theophylline was given to 124 patients along with perceptive treatment,and their blood level of theophylline were analysed. Re-sults; The blood level of theophylline in patients on age 61 -71 group were higher and cardiovascular side effects were more after seen than that of 14 -60 groups( P <0.01). The blood oxygen pressure (P02) might affect the concentration of theophylline,the lower the P02 ,the higher the blood level of theophylline. But combine administration of steroid hormone and β2 - receptor stimulant had no effect on blood level of theophylline. Conclusion; The dosage and dosage -form of theophylline must be individualized according to patient's condition and the blood level of the agent should be monitored. If a single dose of theophylline causes suspectable side effect, the addition of other antiasthmat-ics will be recommended to reduce utmost toxic reaction.