卷曲霉素不良反应的临床观察

Clinical observation on the side effect of CPM

目的 了解卷曲霉素 (CPM )的不良反应。方法 调查 6 1例用卷曲霉素治疗的复治结核病人出现的不良反应。结果 6 1例中出现 14例 ,发生率 2 2 .9%。共出现 5种不良反应 ,其频率依次为肾功能损害、低血钾、第八对颅神经损害、低血钙、局部硬结 ,出现时间多在给药 1个月左右。结论CPM引起的不良反应常见 ,以肾功能损害及电解质紊乱较重 ,应引起临床工作者高度重视。

Objective To observe the side effect of CPM.Methods To investigate 61 retreatment tuberculosis patients who had used CPM and to observe their side effects of CPM.Results 61 patients used CPM.Amony them,14 patients had the side effects.The rate was 22.9%.There were total five kinds of side effects.Frequency of the side effects was renal injury,hypokalemia,Ⅷ cranial nerve's injury,hypocalcium,part's scleroma.The side effect often appeared after the patients using the CPM for a month.Conclusion The side effect of CPM appeared commonly in the clinic,but the renal injury and the disarrangements of electrolytic were more serious.The clinicians shall pay great aftention to this.