空气净化对老年2型糖尿病患者血浆内皮素-1的影响

Effect of air purification on plasma levels of ET-1, SOD, GSH-px and MDA in elderly patients with type 2 diabetes

目的 探讨空气净化对老年 2型糖尿病患者血浆内皮素 1等的改善。方法 老年 2型糖尿病疗养员 43例随机分为空气净化组 (n =2 4 )和对照组 (n =1 9)。空气净化组所处的疗养室进行每日 2 4h空气净化 ,对照组患者住普通病房。两组均每隔 1个月抽血检测血浆内皮素 1、超氧化物歧化酶、谷胱甘酞过氧化物酶、丙二醛和心功能指标。结果 实验组空气净化 1个月后 ,内皮素 1、丙二醛由净化前的 4 .2 3± 1 .1 5pg/ml、4 .58± 0 .44mmol/L分别下降为 3 .41± 1 .2 8pg/ml、4 .1 3± 0 .34mmol/L(P均 <0 .0 5) ,超氧化物歧化酶、谷胱甘酞过氧化物酶由净化前的 82 .3± 8.7nU/ml、44 .7± 5 .9U/L分别上升为 88.5± 9.6nU/ml、57.5± 6 .4U/L ,有效率分别为 75 % ,75 % ,70 .8% ,66 .7%。心功能指标也有明显的改善 (P <0 .0 5)。结论 对老年 2型糖尿病患者行空气净化治疗 ,能显著改善其血浆内皮素 1的含量。

Objective To investigate the effect of air purification on changes of plasma levels of ET 1, SOD, GSH px, and MDA in patients with type 2 diabetes Methods The living rooms of 24 patients with type 2 diabetes were purified with air cleaner (MKJ 800) once a day for 30 days, then the aforementioned parameters were assessed and compared with that obtained at the begining of hospitalization. In patients of the control group (N=19), who lived in the ordinary wards, the changes of these parameters were also evaluated Results The average plasma levels of ET 1 and MDA of patients in the experimental group were markedly decreased (from 4.23±1.15 pg/ml to 3.14±1.28 pg/ml, and 4.58±0.44 mmol/L to 4.13±0.34 mmol/L, respectively), while the plasma levels of SOD and GSH px were significantly increased. Evidence of improved cardiac function were also noted in these patients. Conclusion Room air purification can decrease the ET 1, SOD, GSH px and MDA content of plasma and improve the cardiac function of patients with type 2 diabetes