吸入一氧化氮治疗高原肺水肿疗效对比观察

Observation and comparison to the curative effect of high - altitude pulmonary edema byinhalation of nitric oxide

目的探讨一氧化氮(NO)对高原肺水肿治疗的用量及效果关系。方法64例高原肺水肿患者随机分为3组。常规组(24例)按以往临床常用方法治疗;吸入NO甲组(18例)在常规治疗基础上入院后用BG-951型一氧化氮治疗仪一次性吸入20 ppm NO2 h;吸入NO乙组(22例)在常规治疗基础上入院后用广州军区广州总医院研制的BG-951型一氧化氮治疗仪一次性吸入10 ppm NO 1 h。结果肺部湿性(口罗)音消失时间、肺部X线阴影吸收时间及病程时间吸入NO甲组较乙组及常规组、乙组较常规组均有明显缩短,差异有非常显著性(P<0.01)。结论 吸入NO治疗高原肺水肿疗效可靠,吸入20 ppm NO 2 h用量及疗效最佳。

Objective To study the relationship between the dosage of NO and the effect on high - altitude pulmonary edema. Methods 64 cases of high - altitude pulmonary edema - patients were randomly divided into three groups. Conventional group (24 cases) was treated with conventionaltherapy. For the first group (18 cases), in addition to conventional therapy. A single dose of 20 ppm NO is inhaled for two hours using BG - 951 instrument of inhaled nitric oxide manufactured by Guangzhou military command Guangzhou general hospital; For the second group (22 cases) , in addition to conventional therapy, a single dose of 10 ppm NO is inhaled for one hour using BG- 951 instrument. Results The time with pulmonary rales on auscultation and shadows on chest radiograph , and the course of disease were compared. The first group had significantly shortened time comparing with the second group. The second group had significant shortered time comparing with the conventional group( P < 0.01) . Conclusion Treatment of high - altitude pulmonary edema by inhalation of NO has reliable curative effect. The best curative effect is achieved by inhalation of 20 ppm NO.