治疗抗肿瘤药物导致肝损伤药物的合理使用

Rational use of anti-tumor drugs that can induce liver injury

抗肿瘤药物导致的肝损伤重在预防,需要对药物潜在的不良反应有整体把握,及时诊治和停止引起肝损伤的药物。本文重点介绍抗肿瘤药物引起的肝损伤病理分型、导致途径和机制,以及不同类型保肝药物作用机制和特点。根据不同肝损伤的类型,选择作用机制以及特点不同的保肝药,给予合适的剂型和剂量。同时密切关注患者体征和各种生物学指标,积极进行对症及支持治疗。

Prevention should be emphasized in anti-tumor drugs induced liver injury,which needs integral mastering on the drug potential adverse reaction,diagnosing,treating and stopping the liverinjury drugs in time.This paper emphasizes on pathological types,pathways,mechanisms within anti-tumor drugs induced liver injury and the modes of action,characteristics of different types of liver-protecting drugs.Based on different types of liver injuries,it should select the different mechanisms and characteristics of liver-protecting drugs with proper preparation and dosage reasonable.Meanwhile,patients' physical signs and biological indicators should be paid close attention to,and symptomatic,positive and supportive treatments are also needed.