急性白血病EB病毒抗壳抗原抗体(VCA-IgA)变化的观察

OBSERVATION ON THE CHANGES OF SERUM IgA ANTIBODY TO EPSTEIN-BARR VIRAL CAPSID ANTIGEN IN ACUTE LEUKEMIA

EB病毒(Epstein-Barr Rirus)是在人类B淋巴细胞寄生的疱疹病毒,在人群中广泛传播。在广东省和北京市2,300例正常人血清调查中,90%以上人群在3～5岁时已感染了EB病毒,EB病毒感染后,通常以潜伏感染的形式长期存在于人体内,显性感染则导致传染性单核细胞增多症。许多实验提示,EB病毒和非洲儿童恶性淋巴瘤(Burkitt淋巴瘤)和鼻咽癌可能存在着病因学上的关系,这些肿瘤患者体内常出现高滴度的EB病毒壳抗原(VCA)特异性抗体。其他恶性肿瘤和引起免疫功能不足的疾病,亦常有VCA的IgG型抗体的升高;白血病时这种抗体的升高国外亦有过报道。

Sera from 49 patients (30 male, 19 female) with acute leukemia were measured for IgA antibody to Epstein-Barr viral capsid antigen (VCA-IgA). 12/20 (60%) and 8/29 (27.6%) patients were seropositive for VCA-IgA in lym. phocytic and non-lymphocytic leukemia respectively. Among 23 patients who were followed up, 17 cases had a decreasing titre of VCA-IgA when their illness became better, and 3 cases, an increasing titre when worse. These results suggest that patients with acute leukemia, especially in L_2 subgroup of acute lymphocytic leukemia, have a higher incidence of positive VCA-IgA, This may be a useful tool in reflecting the severity of the illness and assessing the effect of treatment in the seropositive patients.