期刊文献+

慢性荨麻疹临床表现与白细胞介素-31的关系 被引量:7

下载PDF
导出
摘要 目的了解慢性荨麻疹临床表现与白细胞介素-31(IL-13)的关系。方法 ELISA法测定54例慢性荨麻疹患者和23例正常对照者血清IL-31水平,分析IL-31水平与慢性荨麻疹皮肤瘙痒程度、风团数量和风团大小等临床表现的关系。结果慢性荨麻疹患者血清IL-31水平为(286.7±113.5)pg/m L,正常对照者为(92.8±45.3)pg/m L,两者比较差异有统计学意义(t=24.539,P<0.001);血清IL-31水平与慢性荨麻疹皮肤瘙痒程度呈正相关(r=0.28,P<0.05),与风团数量和风团大小无相关性(P>0.05)。结论慢性荨麻疹患者血清IL-31水平升高,针对IL-31的治疗可能对减轻患者的瘙痒症状有帮助。
出处 《广东医学》 CAS 北大核心 2016年第S1期55-56,共2页 Guangdong Medical Journal
  • 相关文献

参考文献1

二级参考文献11

  • 1刘京梅,朱勇,欧阳为明,王九平,庄然,金伯泉.肾综合征出血热患者体内可溶型和膜型TNFα,FasL,TRAIL表达水平的研究[J].免疫学杂志,2006,22(4):426-428. 被引量:4
  • 2Dillon SR, Sprecher C, Hammond A, et al. Interleukin 31 , a cytokine produced by activated T cells, induces dermatitis in mice[J]. Nat Immunol,2004,5(7):752- 760.
  • 3Kim CH, Pelus LM, White JR, et al. CKβ-11/macrophage inflammatory prolein-3β/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells[J]. J Immunol, 1998,160(5) :2 418 - 2 424.
  • 4Kellermann SA, Hudak S, Oldham ER, et al. The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3βare potent chemoattractants for in vitro- and in vivo-derived dendritic cells[J]. J Immunol, 1999, 162(7): 3 859-3 864.
  • 5Kawasaki S, Takizawa H, Yoneyama H, et al. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice[J]. J Immunol, 2001, 166(3):2 055- 2 062.
  • 6Haque NS, Zhang X, French DL, et al. CC chemokine Ⅰ- 309 is the principal monocyte chemoattractant induced by apolipoprotein (a) in human vascular endothelial cells[J]. Circulation, 2000,102(7) : 786 - 792.
  • 7Diveu C, Lelievre E, Perret D, et al. GPL, a novel cytokine receptor related to GPI30 and leukemia inhibitory factor receptor[J]. J Biol Chem, 2003, 278 (50) : 49 850 - 49 859.
  • 8Diveu C, Lak Hal AH, Froger J, et al. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interteukin-31 signaling[J]. Eur Cytokine Netw, 2004, 15 (4) : 291 - 302.
  • 9Takaoka A, Arai I, Sugimoto M, et al. Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis[J]. Eur J Pharmacol,2005,516(2) : 180 - 181.
  • 10Bilsborough J, Leung DY, Maurer M, et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis[ J]. J Allergy Clin Immunol,2006,117(2):418 - 425.

共引文献5

同被引文献52

引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部