血清SALL4浓度与肝细胞癌患者预后的相关性

Correlation between serum SALL4 concentration and prognosis in patients with hepatocellular carcinoma

目的探讨血清婆罗双树样蛋白4(SALL4)浓度与肝细胞癌患者预后的相关性。方法将无法手术治疗的肝细胞癌患者66例,分成未接受任何抗肿瘤治疗的无治疗组42例和接受介入、靶向等非手术治疗的有治疗组24例,首先采集患者临床资料及检验信息,将SALL4浓度、年龄、肝硬化、乙肝、肝功能Child-Pugh分级、诊疗规范分期、甲胎蛋白(AFP)浓度等因素纳入Cox回归分析,得到与两组患者生存时间相关的因素。再用Kaplan-Meier生存分析探讨两组患者不同因素与生存时间的关系。结果将血清SALL4浓度≥800 ng/mL定义为高浓度,反之为低浓度。在无治疗组,血清SALL4浓度的高低与肝细胞癌患者预后无关,两种类型患者生存时间的差异无统计学意义(P=0.798);在有治疗组,血清SALL4低浓度患者的生存时间长于高浓度者,差异有统计学意义(P=0.019)。结论对于不进行任何治疗的肝细胞癌患者,血清SALL4浓度的高低不能反映患者的预后;对于接受非手术治疗者,血清SALL4浓度低者较浓度高者预后好。

Objective To investigate the correlation between serum SALL4 concentration and prognosis of patients with hepatocellular carcinoma(HCC).Methods Sixty-six patients with HCC who could not be surgically treated were divided into no treatment(without any anti-cancer treatment)group(42 cases)and treatment(interventional treatment,targeted treatment,or other non-surgical treatments)group(24 cases).Clinical data of the patients,such as SALL4 concentration,age,liver cirrhosis,hepatitis B,Child-Pugh classification,staging,and AFP concentration were collected into Cox regression analysis.Kaplan-Meier survival analysis was used to investigate the correlations between SALL4 concentration or other factors and survival time.Results The serum SALL4 concentration≥800 ng/mL was defined as a high concentration,otherwise it was low concentration.Survival analysis showed no significant difference in survival time between patients with high and low serum SALL4 in the untreated group(P=0.798).In the treated group,patients with low serum SALL4 had significantly longer survival than those with high concentration(P=0.019).Conclusion For patients with HCC who do not receive any anti-cancer treatment,the level of serum SALL4 concentration does not reflect the prognosis of patients.But for the patients who receive non-surgical treatment,patients with low serum SALL4 concentration have a better prognosis.