阿尔茨海默病危险因素研究

Risk factors of Alzheimer's disease-a Case-control study in shanghai.

目的:研究中国人阿尔茨海默病危险因素和保护因素,以期为AD病因学的研究和预防提供资料。方法:采用1:1的病例对照研究方法。病例和对照各111例。结果:经单因素分析后,各变量值包括散步,跑步和打拳等运动项目中各年龄段不运动的人患AD的危险性高于参加这些运动的人,有过神志不清的人患AD危险性高于对照组。服用含铝抗酸剂的人患AD危险性高于对照组。将单因素卡方分析P<0.4的变量建立多因素回归模型,采用条件Logistic回归,50岁及以后不散步、不跑步、家中无煤气、25岁～49岁不打拳、出生时母亲年龄偏大、家中排行递增Logistic回归系数分别为0.646、0.982、2.199、0.02、0.02、吃饱、未曾服用过含铝抗酸药、镇静药、没有关节炎的Logistic回为系数分别为-0.78、-2.147、-1.383、-0.397。结论:运动是AD的保护因素,出生时母亲年龄偏大、家中排行递增和含铝抗酸药等使患AD的危险性增加。

Objective: To study risk factors and protective factors of Alzheimer's disease (AD) in Chinese community-based population, to provide findings of the prevention and etiology research of(AD). Methods:111 couples case-control study. Result: Ten factors were associated with risks of AD,including no walking, no running, no coal gas after their 50 year old, no boxing from 25 to 49 year old, high maternal age at birth, increasing of siblings had positive relationship with AD, while hungry, no taking anti-acid agents with aluminum, sedatives, no arthritis had negative rela-tionshop with AD, when tx2 test, the positive coefficients of these factors in multi-varible logistic regression model were 0. 646,0. 982,2. 199,0. 01,0. 02,while the negative coefficients of these factors were -0.780, -2.147, -1.383, -0. 397. Conclusion: Exercises were protective for AD,while high maternal age at birth, increasing of siblings, hungry and taking anti-acid agents with aluminum, sedatives were risk factors of AD.