DC-CIK联合化疗治疗结肠癌25例疗效分析

DC-CIK Combined with Chemotherapy for Colonic Cancer:An Analysis on the Effect of 25 Cases

为探讨树突状细胞诱导的杀伤细胞(DC-CIK)联合化疗治疗结肠癌的疗效,将结肠癌患者50例随机分为单纯化疗方案组和DC-CIK联合化疗方案组,每组25例。单纯化疗方案组采用单纯化疗方案治疗,DC-CIK联合化疗方案组在单纯化疗方案组治疗的基础上加DC-CIK治疗,比较2组患者的疗效、平均生存期、治疗前后患者生命质量不同领域测评值以及细胞免疫功能及不良反应发生率。结果显示,DC-CIK联合化疗方案组在疗效、平均生存期、生命质量不同领域测评值以及细胞免疫功能方面均优于单纯化疗方案组(P <0.05)。DC-CIK联合化疗方案组不良反应发生率低于单纯化疗方案组(P <0.05)。结果表明,DC-CIK联合化疗方案治疗结肠癌疗效显著,可延长患者生存期,改善患者的细胞免疫功能和生存质量,降低化疗不良反应发生率。

This study was to investigate the effect of dendritic cell-cytokine induced killer(DC-CIK)combined with chemotherapy for colonic cancer,randomly divided 50 patients with colonic cancer into simple chemotherapy group(25 cases,alone chemotherapy)and DC-CIK combined with chemotherapy group(25 cases,i.e DC-CIK plus chemotherapy);then compared both groups’effect,average survival duration,the measure&evaluation value at different areas in quality of life,cellular immuno-function,as well as untoward reaction incidence.As results,in all above-mentioned indexes combination group was all superior to simple chemotherapy group(all,P<0.05),except for untoward reaction incidence being lower than simple chemotherapy group significantly(P<0.05).Results show that combination therapy for colonic cancer can achieve great effect,lengthen patient’s survival duration,improve their cellular immuno-function and quality of life,and decline the incidence of chemotherapy induced untoward reaction.